A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Paracetamol (PAR) through FT-IR in combined dosage form. The method involves the measurements of peaks of carbonyl group (C=O) at 1656 cm-1 (PAR) and 1717 cm-1 (DMP). An UV-Spectrophotometric method was also described for the simultaneous determination of DMP and PAR. The analytical results obtained with FT-IR showed very good correlation with UV-Spectrophotometric method. The method was validated for pharmaceuticals in tablet form and found to be highly precise with high recovery levels (>99%).