There is a tremendous growth in pharmaceutical industry in the recent years due to rapid drug discovery and development of new drug processes. This has increased the frequency of release of newer drugs in to the pharmaceutical market and proportionally demanded the development of newer analytical methodologies using various analytical techniques. A simple Fourier Transform Infrared (FT-IR) spectroscopic method has been developed for the quantification of Domperidone (DMP) and Omeprazole (OMP) in combined dosage formulations. The method involves the measurement of peak absorbance of carbonyl group (C=O) at 1717 cm-1 for domperidone and imine group (C=N) at 1627 cm-1 for omeprazole. The method was found to be highly precise with %RSD less than 2 and % recovery levels >99. The developed method can be adopted for routine analysis in pharmaceutical industry.