This study was carried out to assess the quality of four brands of locally produced amodiaquine tablets in Accra, Ghana. The assayed samples were characterized for their weight, percentage active ingredients, and percentage active ingredient released during dissolution. All the tablets sampled were within their shelf life period as well as possessing good physical characteristics. Samples from the examined manufacturers were assayed to determine the percentage of active ingredient within the tablets and. Assayed amodiaquine samples from MCI, MC2 and MC4 manufacturers passed the test of percentage active ingredient within the tablets in compliance with British Pharmacopoeia requirement. However, MC3 recorded a higher percentage which could be due to a high amount of active ingredient added. All the samples had good results in the uniformity of weight test, which could be due to free flow of granules during tableting. All the tablets sampled complied with standards with regards to dissolution which could be due to the amount or type of binder used. Therefore based on the findings of this study, amodiaquine tablets manufactured by the local manufacturers are in general of good quality.