Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 6

QSAR Studies of 6-aryl- 6H-pyrrolo [3, 4-d] pyridazine analogues as high-affinity ligands of the ?±2?´subunit of voltage-gated calcium channels


The anticonvulsant activity of 6-aryl- 6H- pyrrolo (3, 4-d) pyridazine (PPZ) analogues was quantitatively analyzed in terms of physico chemica l parameters by regression analysis. Structural requirements for maximal binding affinit y to a novel site of α 2 δ subunit were derived. The leave –one –out cross validation method was use d to judge the predictive power of model equations. The high binding affinity of molecule is expected to have more bulky and electron donating groups.