Lead intoxication may initiate many disorders in humans and animals. This study investigated the role of Tagetes erecta in protecting rats against lead exposures. The results showed that the administration of Tagetes erecta efficiently protected albino rats against the lead caused injury, as revealed by some improvement in the enzymatic antioxidant (SOD, CAT and GPx), nonenzymatic antioxidant (GSH, Vit-E and Vit-C ) activities. Thus,this suggests the possibility of T.erecta usefulness in limiting toxicant induced by environmental heavy metals.