Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2018 Vol: 10 Issue: 8

Preparation of Mg/Al-Layered Double Hydroxide and Its Application in the Synthesis of 3,4-Dihydropyrimidin-2(1 h)-Ones

Abstract

An efficient green protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (DHPM) using Mg/Al-LDH (3:1) as heterogeneous base catalyst has been developed. The Mg/Al-layered double hydroxide was prepared by co-precipitation method, with ratio Mg2+/Al3+ = 3, at pH 10. And the physicochemical characterization has been done by XRD, TG-DTA, IR and BET. In this paper, we have reported the synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones (DHPM) by treating substituted aromatic aldehydes with urea and ethyl acetoacetate in (1:1:1) mole ratio in the presence of Mg/Al−LDH (3:1) as a catalyst. The attractive features of this protocol are: mild reaction conditions, good yields and easiness of the catalyst separation from the reaction mixture.

http://sacs17.amberton.edu/

rtp slot demo