Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2018 Vol: 10 Issue: 7

Preparation, Identification, Isolation and Characterization of Impurity in Cefoxitin


The preparation and isolation for impurities (2R,6R,7S)-3-((carbamoyloxy)methyl)-7-methoxy-8-oxo-7- (2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid (A),(6R,7S)-3- ((carbamoyloxy)methyl)-7-methoxy-7-((R)-2-methoxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (B),(6R,7S)-3-((carbamoyloxy)methyl)-7-methoxy-7-((S)- 2-methoxy-2- (thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (C) of cefoxtin were firstly described. These impurities are characterized by NMR and HRMS spectral data. These findings could be important for quality control and validation of the analytical method in the manufacture of cefoxitin.