Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 6

Preparation, characterization and antiulcer activity of mixed ligand complex of Zn (II) with Famotidine and Glycine

Abstract

Mixed ligand complex of Zn(II) with famotidine and glycine has been prepared. The complex has molecular formula as [Zn(fam)(L)]NO 3 ; where fam = famotidine and HL = glycine. The complex has been characterized by elemental analysis, electronic and IR spectra and the particle size of the complex has be en measured by microscopic method. Pharmacological activity of the complex on gastric secretion in pylorous ligated rates and gastric emptying rate in albino rats has been studi ed. The complex has significant reduction in total and free acid on gastric secretion. However, there is no significant change on gastric emptying rate. Mixed ligand complex of Zn(II) with famotidine and glycine has been prepared. The complex has molecular formula as [Zn(fam)(L)]NO 3 ; where fam = famotidine and HL = glycine. The complex has been characterized by elemental analysis, electronic and IR spectra and the particle size of the complex has be en measured by microscopic method. Pharmacological activity of the complex on gastric secretion in pylorous ligated rates and gastric emptying rate in albino rats has been studi ed. The complex has significant reduction in total and free acid on gastric secretion. However, there is no significant change on gastric emptying rate.