Binder properties of mucilage of starch extracted from Annona reticulata fruits were investigated in paracetamol tablet formulations prepared via wet granulation method. The starch paste in four concentrations (2.5%, 5%, 7.5% and 10%w/w) was evaluated for optimized binder concentration. Preformulation study of the drug with starch were analysed using Fourier transform infrared spectroscopy (FTIR) Preformulation study of the drug and starch showed no interaction in FTIR. The tablets were evaluated for physical properties, disintegration time and in vitro dissolution profiles, and all the parameters were found within the official specifications. The effect of binder on tablet properties was related to their viscosity and surface tension. Tablets at 7.5% w/w binder concentration showed more optimum results. Results suggest the suitability of Annona reticulata fruit mucilage as a binder to paracetamol tablets.