Andrographis peniculata (Acanthaeceae) is a traditional Indian herb used historically as support for a healthy immune system. The following study was carried out using excision wound model in order to establish the wound healing activity of the drug on Swiss Wistar strain rats of either sex. The treatment was continued till the complete healing of the wound. For topical application, 2%w/w ointment of ethanolic extract and petroleum ether extract was prepared in 2% w/w PEG-4000; the control group of animals was left untreated. It was observed that there was complete healing on 12th post wounding day by applying both the extract. The wound contractions on 12th day in petroleum ether extract, ethanolic extract were shown to be 10.17±0.60 and 16.33±0.67 respectively. The healing was assessed by the rate of wound contraction. Andrographis peniculata ethanolic extract possesses better wound healing property in comparison to control and also with petroleum ether extract.