Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 3

Potentiometric study of stability constant of binary and ternary complexes of Enalapril with transition metal ions in aqueous solution


Mixed ligand stability constants of Co(II),Ni(II),Cu(II) and Zn(II) complexes with enalapril drugs (LP) and Glycine (LS) have been determined pH metrically at room temperature and 0.01 M ionic Strength (NaClO4) in aqueous solution. The formation of various possible species has been evaluated by computer program and discussed in terms of various relative stability parameters. The ternary complexes shows, stability order as Δlogk = 1:1:1 Co(II)>Ni (II)>Cu(II))>Zn(II) 1:1:2 Ni(II)~ Zn(II)>Co(II)>Cu(II)

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