The methanolic extract of Momordica cochinchinensis was subjected to preliminary phytochemical studies. The results indicate the presence of glycosides, flavonoids, carbohydrates and phytosterols. Antimicrobial activity was screened by using agar well diffusion method. The results revealed that the methanolic extract exhibited significant anti-microbial activity at concentration of 100-500 μg/ml respectively against tested organisms, particularly more effective against gram(+)ve bacteria Staphalococus aureus, and gram (- ) ve bacteria Esherichia coli. than the aqueous extract when compared to the standard drug (Ampicillin). Antioxidant activity by DPPH method shows better results for test drug when compared to the standard drug (ascorbic acid).