Original Articles: 2011 Vol: 3 Issue: 5
Phytochemical evaluation by GC-MS and antihyperglycemic activity of Mucuna pruriens on Streptozotocin induced diabetes in rats
The aim of the this study was to identify the phytochemical constituents of Mucuna pruriens extract by Gas Chromatography – Mass Spectrophotography (GC-MS) and to evaluate the hypoglycemic potential in streptozotocin induced diabetic rats. The rats were treated orally with the extract at 100 mg and 200 mg /kg b wt for 21 days. Biochemical parameters viz., fasting blood glucose (FBG), blood urea, serum creatinine and total cholesterol were analyzed. GC-MS analysis showed the presence of phytochemicals like n-hexadecanoic acid (48.21 %), Squalene (7.87%), Oleic acid (7.62%) ascorbic acid (3.80%) and Octadecanoic acid (6.21%) were present in the extract. Mucuna pruriens reduced the blood sugar of diabetic rats from 242. 4 ± 9.2 mg/dl to 91.0 ± 5.2 mg/dl. Thus, Mucuna pruriens show a good potential of being used as alternate medicine in the treatment of diabetes mellitus.