Sweet lime (Citrus limettarisso) is also known as ‘Mosambi’ in the Indian subcontinent region. It has multiple pharmacological effects and its constituents are extensively utilized for many clinical applications. Traditionally it has been widely used in the treatment of the scurvy, indigestion and constipation, diabetes, ulcers, urinary disorder and for improvement of immune system. Advancement in analytical techniques led to identification of multiple constituents among which d-limonene was found to be in abundant. Being chief component of Citrus limetta and having better pharmacokinetic and pharmacodynamics properties of d-limonene, it is worth full to explore it in detail. This study is focused on highlighting the phytochemical investigations, traditional uses and clinical applications of Citrus limetta as well as its chief constituent-limonene, which provides approval for further pharmacological and clinical investigations.