Phytochemical and antibacterial property of crude petroleum ether, chloroform, acetone, methanolic and aqueous extracts of Jatropha curcas L leaves were studied as part of searching new bio-active compounds. The extracts of J. curcas revealed the presence of saponins, steroids, alkaloids, phenolic groups and flavonoids. Antibacterial activity of J. curcas showed varied degree of zone of inhibition against the tested bacterial pathogens. Chloroform extracts of J. curcas showed the broadest spectrum of antibacterial activity and the maximum zone of inhibition 10 mm were observed against E. coli and S. aureus. Petroleum ether extract exhibited antibacterial activity against Proteus sp. and P. aeruginosa with the zone of inhibition of 10 and 4 mm respectively. Methanolic extract of J. curcas proved the antibacterial activity against three pathogens except S. aureus. Acetone extract revealed the antibacterial activity against S. aureus only.