Furan ring systems are abundantly available in secondary plant metabolites. Due to their remarkable properties, many synthetic furans are utilized as pharmaceuticals. Hence a series of N-(furan-2-ylmethylene) benz- imines derivatives has been synthesized by reaction between furan-2--carboxaldehyde and various aromatic anilines to yield the schiff, s bases. The newly synthesized compounds showed potent CNS depressant and analgesic activities. Prior to determination of the Pharmacological activity LD50 was determined. The pharmacological data obtained were tested for statistical significance.