Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 11

pH-metric study of substituted thiopyrimidine complexes in mixed solvent media

Abstract

The solution studies the proton-ligand stability constant pK and metal-ligand stability constants logk of binary (1 : 1) complexes of Ni(II), Cu(II) and Zn(II) with substituted thiopyrimidine drugs have been studied at 0.1M ionic strength in 70 % DMF-water mixture by Bjerrum method as adopted by Calvin and Wilson. It is observed that Ni(II), Cu(II) and Zn(II) metal ions form 1:1 and 1:2 complexes with ligands (L1& L2).The data obtained were used to estimate and compare the values of proton-ligand stability constant (pK) and metal-ligand stability constants (logk). From estimated data (pK and logk), the effects of substituents were studied.