Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 4

Phenolic Compounds from Grape Wastes and their Impact in Neurodegenerative Disease

Abstract

Twelve phenolic compounds were isolated from Thompson seedless grape and Grenache Noir (GN) wastes. These compounds were identified as quercetin 3-O-β-D-glucopyranosyl (1→2)-O-β-D-glucopyranoside, quercetin-3-O-α- L-rhamnopyranosyl (1→6)-O-β-D-glucopyranoside, quercetin-3-O-β-D-glucopyranoside, kaempferol-3-O-β-Dglucopyranoside, kaempferol-3-O-β-D-galactopyranoside, kaempferol-7-O-β-D-glucopyranoside, quercetin, catechin, isorhamnetin, gallic acid, cinnamic acid and ferulic acid. All structures were characterized by spectroscopic analyses and comparisons with the previously reported data. Two of the isolated compounds, gallic and catechin revealed a power full antioxidant activity which due to its hydroxyl groups. The present study has been designed also to explore the possible role of grape pomace extract against aluminium chloride-induced neurotoxicity in rats. Aluminium chloride (70 mg/kg) was administered daily for six weeks that significantly increased cognitive dysfunction and oxidative damage as indicated by a rise in nitrite oxide concentration. Chronic administration of grape pomace extract (13 and 129 mg/kg) daily to rats for a period of 6 weeks significantly improved the memory performance tasks of rats, attenuated oxidative stress (superoxide dismutase and catalase), decreased acetylcholinesterase activity. Results showed that BDNF, Bcl-2 and AChE return to their normal value after administration of the extract. This study demonstrated the neuroprotective potential of grape waste extract in aluminium chloride-induced cognitive dysfunction and oxidative damage.

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