Postoperative nausea, retching and vomiting are among the most common postoperative complaints and key causes of morbidity after general, regional, or local anesthesia and surgery. To study the clinical effect of ondansetron on patients with gynecologic laparoscopic operation. We performed a comparative-analysis of published, randomized, controlled trials to determine the relative efficacy and safety of ondansetron for prevention and treatment of postoperative nausea and vomiting. The results demonstrated that the prophylactic administration of ondansetron was more effective in preventing postoperative vomiting, but the drug were compared with placebo. The overall risk of adverse effects was not different.