Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2012 Vol: 4 Issue: 8

?Ž?²-Oxoanilides in heterocyclic synthesis : Synthesis of Some New Pyrimidine containing Sulphonamido moiety Derivatives


Butanamide derivative (1) coupls smoothly with arenediazonium salts to afford the hydrazone (3). The latter product reacts with dimethylformamide – dimethylacetal (DMF-DMA) and or malononitrile to afford the substituted 1,4- dihydropyridazines (5,6). Several new pyran (8), thiophene (9), pyrazole (14) and isothiocyanate derivatives (17,18) have been synthesized by the reactions of butanamide with 4-chloro-benzylidenemalonitrile, malononitrile and elemental sulfur, and hydrazine hydrate respectively. Refluxing of butanamide (1) with p-chlorobenzaldhyde afforded compound (10). Treating butanamide derivative (1) with (DMF-DMA) afforded compound (11) and when reacting with triethylorthoformate and hydroxylamine hydrochloride afforded compounds (13, 15). Treating of sulfonamide with thiophosgene afforded isothiocyanate product (16) which on refluxing with p-toulidine or methanol afforded compounds (17, 18) respectively.

rtp slot demo