Original Articles: 2011 Vol: 3 Issue: 3
Oral sustained delivery of Ranitidine from in-situ gelling sodium-alginate formulation
The experiment was conducted to make the formulation to release drug (Ranitidine) for an extended period of time and buoyant, thus prolong the residence time. Sodium alginate used as a polymer. Sols of Sodium Bicarbonate and Calcium carbonate was prepared. In the present study the Calcium ions released from Calcium carbonate are complexed by Citrate. The conversion of complexed Calcium into free Calcium cause gelation of Alginate. The gelled material floats upwards in the stomach, with a potential to release the drug from the formulation. It is established that the formulation containing Calcium carbonate produce a significant stronger gel than those containing Sodium bicarbonate due to internal gelation effect of calcium on gellan. Ranitidine from floating in-situ gels with D-sorbitol is the best suitable form for paediatrics and geriatrics and also for patients with difficult in swallowing.