In oral glucose tolerance tests conducted with methanolic extract of fruits of Momordica cochinchinensis, the extract at doses of 50, 100, 200 and 400 mg per kg dose-dependently reduced blood glucose levels in glucose-loaded mice by 23.6, 27.4, 39.5, and 47.5%, respectively. A standard antihyperglycemic drug, glibenclamide, at a dose of 10 mg per kg, reduced blood glucose level by 35.4%. In standard acetic acid-induced pain model in mice, the extract at the afore-mentioned four doses reduced the number of pain-induced abdominal constrictions in mice, respectively, by 44.1, 50.0, 52.9, and 55.9%. A standard analgesic drug, aspirin, when administered to mice, reduced the number of abdominal constrictions by 47.1 and 61.8, respectively. Taken together, the methanolic extract demonstrated significant antihyperglycemic and analgesic potential and so can be a source for efficacious blood glucose lowering and pain-relieving drug(s).