+44 1625708989Original Articles: 2014 Vol: 6 Issue: 4
One-pot three-component condensation for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles using cesium fluoride as an efficient catalyst
Abstract
A clean and simple synthesis of 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3‑c]pyrazole-5- carbonitriles was accomplished in good to excellent yields via the one-pot three component condensation of 3- methyl-1-phenyl- 2-pyrazolin-5-one, an aromatic aldehyde, and malononitrile catalysed by Cesium Fluoride in ethanol.