Objective: The research aims to present the off-label use of drugs in pediatrics. Methods: A systematic review of the databases: LILACS, SciELO, MEDLINE and BVS, with keywords in Portuguese and selected in consultation with the English (DeCS) of Bireme: Off label, drug prescriptions, pediatrics. They included articles published between 2010 and 2016 in national and international journals on the study of the subject so it was selected 7 items to compose the study. Results and discussion: Among the drugs prescribed for off-label use was observed salbutamol in above recommended by the bull doses, Loratadine and dexclorfeniramina for infants, the age at which these drugs are not recommended, Dimethicone, in overdose, dipyrone not approved FDA due to severe cases of agranulocytosis, among others. It was reported no negative reaction to the patients in the studies associated with off-label use, but for reasons connected with the safety of children, does not seem acceptable that can be used in an uncontrolled manner a drug in situations that are not indicated. Conclusion: Therefore, the physician must be attentive to the details of pharmacologic therapy in children, avoiding reactions and ensuring the effectiveness of treatment.