Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective therapy for ocular diseases, especially for the pos terior segment, has been considered as a formidable task. Limitations of conventional route of administration have challenged scientists to find alternative mode of administration like perioc ular routes. Targeted drug delivery has generated a great deal of interest in the field bec ause of its potential to overcome many barriers associated with current therapy. Application of nan otechnology has been very promising in the treatment of a gamut of diseases. In this review, w e have briefly discussed several novel ocular drug delivery systems such as microemulsions, nanos uspensions, nanoparticles, liposomes, niosomes, dendrimers, implants, and hydrogels. Curr ent momentum in the invention of new drug delivery systems hold a promise towards much improv ed therapies for the treatment of vision threatening disorders.