A series of methacrylate polymers derived from 4-chloro-3,5-dimethyl phenyl methacrylate (CDMPMA) with comonomer tetrahydrofurfuryl methacrylate (THFMA) were synthesized via free radial polymerization technique. The copolymers were characterized by fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (1H-NMR), thermogravimetric analysis (TGA) and gel permeation chromatography (GPC). All polymers were thermally stability up to 200ºC under nitrogen atmosphere. The reactivity ratio of monomers in copolymer was obtained by different linearization methods using 1H NMR data. Antimicrobial activities of the homopolymers and copolymers were investigated for various microorganisms such as bacteria, fungi and yeast.