Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Reviews: 2020 Vol: 12 Issue: 4

NIR Spectroscopy: An Advancing Versatile Tool for Process Analytical Technologies in Pharmaceuticals


Near-Infrared (NIR) Spectroscopy and imaging are fast and nondestructive analytical techniques that provide chemical and physical information of virtually any matrix. The Process Analytical Technology (PAT) promoted by the Food and Drug Administration (FDA) has motivated the Pharmaceutical Industry to increase utilization of newer analytical technologies to perform fast measurements of the critical quality attributes of Pharmaceutical materials, starting from raw materials and intermediates to finished products. PAT concept aims ensuring a predefined final product quality. Near IR spectroscopy is a tremendous and prevailing tool for Process Analytical Tool in Pharmaceutical Processes with applicability in multi-functional faces. NIR spectroscopy has been proved to be the most compatible technology with PAT. The present review is aimed to reconnoiter various applications of NIR spectroscopy with special emphasis on Pharmaceutical Processes involved in manufacturing of various dosage forms. The review will also discuss some points to be considered in implementing NIR as a process analytical tool.