Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2021 Vol: 13 Issue: 7

New terpenoides and Steroids from Syzygium cumini Barks


A new pyrazole like compound namely, (E)-4-((2-hydroxy-1-phenylethylidene) amino)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (HEDP) and its Ni (II), Fe (III) and Zn (II) metallic complexes have been synthesized. These testers had characterized from side to side spectral and orderly ways and means. At liberty ligand behaves as tridentate with hydroxyl, carbonyl and imine moiety were co-ordination sites. The FT-IR stretching frequency for the above co-ordination sites were varied after co-ordination with Ni (II), Fe (III) and Zn (II) metallic salts. The octahedral geometry of the metallic multiplexes were confirmed by spectral techniques such by way of UV-Vis, FT-IR, 1H-NMR, 13C-NMR, ESI-MS moreover EPR. Living doings of the ligand and over its multiplexes devour be located verified by anti-oxidant reading, anti-microbial strains such as Escherichia - coli, Staphylococcus aureus, Candida albicans (227) and Penicillium chrysogenum or P.notatum. Metallic multiplexes took larger living events than free HEDP. The computational analysis like biological activity prediction, quantitative prediction of anti-target interaction, cell line cytotoxicity and docking of the samples were done with online software and commercial docking software.

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