The synthesis, physico-chemical characterization and antimicrobial activity studies of new nickel(II) mixed ligand complexes of dithiocarbamates (dtc) with a Schiff base, ethylsalicylaldiminate (EtSal) are reported. The dithiocarbamate ligands are pyrrolidyl (Pyrrol), piperidyl (Pip), morpholyl (Morph), anilyl (Anil), p-chloroanilyl (p-Anil), p-toluidyl (p- Tol) and p-anisidyl (p-Anis). Elemental analyses correspond to 1:1:1 stoichiometry of the nickel(II) ion to the ligands. Infrared spectra reveal bidentate coordination of the ligand moieties to the nickel(II) ion through azomethine nitrogen, phenolic oxygen and both sulphur donor-atoms. Room temperature magnetic moments and solid reflectance spectra data of the complexes are consistent with diamagnetic, square planar geometry. Some of the complexes show moderate to high activity against some test microorganisms.