The synthesis of Nd (III) complexes derived from Schiff base ligands. Obtained by the condensation of 1 napthylamine with different aldehydes viz. 4 hydroxy benzaldehyde ,4 methoxy benzaldehyde, 3 nitro benzaldehyde,4 chloro benzaldehyde were synthesized in alcoholic medium. The prepared Schiff bases and their Nd (III) complexes were characterized on the basis of elemental analysis, IR, 1HNMR, Mass spectral studies. The compounds have been screened for Antimicrobial activity against the organisms Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Basillus subtilis. The antifungal Activities of complexes were tested using fungal species such as Aspergillus Niger and Pencillium Crysogenum. Some complexes showed good antibacterial activities against the tested bacteria therefore, the possible use of the Complexes as antibiotic can be suggested.