Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 7

Naringin Attenuates DMBA-Induced Mammary Carcinogenesis in Rats via Regulating the Oxidative Stress and Antioxidants Status


The present study was aimed to investigate the antioxidant and anti-carcinogenic efficacy of naringin on DMBA-induced mammary carcinogenesis in Sprague Dawley (SD) rats. Female SD rats were induced orally with a single dose of DMBA (80 mg/kg b.wt). Naringin (30 mg/kg b.wt. twice a week) was orally administered before and after tumor induction for 16 weeks. The levels of serum tumor markers viz. CEA, AFP and CA 15-3 were quantified by ELISA method. Biochemical analysis showed that serum LPO, NO, AST, ALT, ALP, ACP, LDH, 5'ND and GGT were increased while enzymatic and non-enzymatic antioxidants were significantly (P<0.05) reduced on DMBA-induced rats. Interestingly, naringin treatment inhibited the incidence rate and tumor volume as well as regularized the levels of biochemical parameters and antioxidants. Additionally, altered ductal epithelial architectures and membrane ruffles were recovered upon naringin treatment as revealed in histological and scanning electron microscopy respectively. Together, our results suggest that naringin could attenuate the mammary carcinogenesis by balancing the oxidative stress and augmenting antioxidant status.