Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Reviews: 2016 Vol: 8 Issue: 2

Nano formulation: A novel approach for nose to brain drug delivery


Nano technology plays a unique and pivotal role in the development of brain specific drug delivery, imaging and diagnosis. Targeted drug delivery is a means of concentrating dugs at a specific site relative to other parts of the body. It spares the rest of the body from toxic effects of the drug and is also a potential means of improving therapeutic index. The delivery of drugs to the CNS is of prime importance for treating specific neurological disorders and various diseases such as Meningitis, Encephalitis, degenerative diseases such as Alzheimer, Parkinson’s and tumors such as Glioblastoma. The major problem in treating such CNS disorders is due to their inability to surpass the natural CNS protective barriers, mainly the Blood Brain Barrier and the Blood cerebrospinal fluid Barrier. Nanoparticle systems in CNS targeted drug therapy provide better penetration of therapeutic and diagnostic agents, and a reduced risk in comparison to conventional treatments. By using nanotechnology it is possible to deliver the drug to the targeted tissue across the BBB, release the drug at a controlled rate, and avoid degradation processes. Different types of nanoparticles used for CNS targeted drug delivery like inorganic nanoparticles, Polymeric Nanoparticles, Solid Lipid Nanoparticles, Nano crystals, Carbon nanotubes, Dendrimers, Gold Nanoparticles and Magnetic Nanoparticles.