Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Multicomponent Biginelli,s synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones catalyzed by Phenyl phosphonic acid


An efficient protocol has been developed for the Biginelli reaction using Phenyl phosphonic acid (PPA) as a novel acid catalyst by a three-component condensation of β-keto ester, aldehydes, and urea or thio-urea to give corresponding 3, 4-dihydropyrimidin-2(1H)-ones.