Multicomponent reactions (MCR’s) are attracting attention of chemist as one of the most powerful synthetic tools for the development of molecular diversity and complexity. It is also useful in synthesis of various heterocyclic compounds. Many of the heterocyclic compoundshave been reported to possess anti-inflammatory activity. This review provides readers with an overview of the exploitation of multicomponent reactions for the synthesis of nonsteroidal anti-inflammatory drugs. Multicomponent reactions are more efficient, cost effective and economical than traditional methods. Literature survey reveals that various multicomponent reactions are exploited for the synthesis of new non-steroidal anti-inflammatory drugs like Biginelli reaction, Ugi reaction, Kabachnik field reaction, Hantzsch reaction, Petasis reaction, Mannich reaction etc.