In the present study, the ultrasonic velocity for Hydroxy propyl methyl cellulose (HPMC) in Sodium Lauryl Sulphate (SLS) and in Sodium Acetate Trihydrate (SAT) have been measured in the concentration range of 0.2%-1.2% at different temperatures (303K, 313K and 323K). Using the measured values of ultrasonic velocity, density, viscosity and other related thermodynamic parameters such as adiabatic compressibility, intermolecular free length, acoustic impedance, solvation number, relaxation time and internal pressure have been evaluated. These parameters have been utilized to study the strong solute-solvent interactions in these systems. The ultrasonic velocity shows a maxima and adiabatic compressibility in corresponding minima with a function of concentration for these blends. The trends in the variation of the solution property parameters indicate the existence of positive molecular interactions of the surfactant and polymer aqueous solutions. The results also indicate the presence of higher values of interactions between HPMC and SAT in solution compared to HPMC and SLS.