Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 6

Microwave Irradiated Convenient Synthesis of 1, 2, 3, 4-Tetrahydropyrimidine-5-Carbonitrile Derivatives


A multicomponent reaction involving one-pot reaction of ethylcyanoacetate, Urea and arylaldehydes in presence of p-TSA, reflux or MWI. Aldehyde (3 mmol), ethyl cyanoacetate or phenyl acetic acid (3 mmol), urea (4.5 mmol) and p-TSA were mixed by stirring in a 25 mL round bottom flask for specified time at a temperature of 70°C, reflux for 7-9 h or MWI with 6-8 mins. (Scheme I). The products were further confirmed by spectral analysis data.

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