A microwave intervened synthesis of tri substituted pyridine subsidiaries by a three-segment response of chalcones, 3-aminobut-2-enenitrile, and ammonium acetate managed 2,4,6-trisubstituted pyridine-3-carbonitrile derivatives in reasonably good yields. FTIR, NMR, HRMS and SCXRD built up the structures of all new compounds.