Microwave assisted synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl- 2-oxo-4-arylpyrimidine-5-carboxamide and 3, 4-dihydropyrimidin-
2(1H)-ones under solvent free conditions

I. T. Phucho; S. Tumtin; A. Nongpiur; R. Nongrum; R. L. Nongkhlaw

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 3

Microwave assisted synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl- 2-oxo-4-arylpyrimidine-5-carboxamide and 3, 4-dihydropyrimidin- 2(1H)-ones under solvent free conditions

Abstract

6-Methyl-1,2,3,4-tetrahydro-N-aryl-2-oxo-4-arylpyrimidine-5-carboxamide and 5-unsubstituted 3, 4-dihydropyrimidin-2(1H)-ones have been synthesised from three component cyclocondensation of N-aryl-3-oxobutanamide/acetophenone, aldehyde and urea /thiourea in presence of PTSA under solvent free microwave irradiation.