Microcrystal cellulose is a result from alpha cellulose isolation. Woody plants are generally the source for microcrystal cellulose production. One of the natural ingredients that can be used to make microcrystalline cellulose is sugarcane bagasse (Saccharum officinarum L.). Sugarcane bagasse contains 37.65% cellulose which can be isolated by delignification steps using base solution, bleaching process, and alpha cellulose hydrolysis with high temperature heating using dilute acid solution. Microcrystal cellulose yield from sugarcane bagasse was 26.03% and fulfilled the characteristic based on literature. Microcrystal cellulose has a potential to be used as tablet filler ingredient which fulfill tablet physical property test.