Alprazolam is a known sedative and hypnotic drug. A simple visible spectrophotometric method is developed and validated for Alprazolam in its pharmaceutical dosage, using 2, 3 dichloro 5, 6 dicyano 1, 4 benzoquinone (DDQ) at 380C . The maximum absorbance of Alprazolam is found to be at max l =266 nm. On reaction with DDQ solution Alprazolam forms yellow colored salt derivative with maximum absorbance at max l =426nm. The solution obeys Beer’s law in the concentration range of 1-20m g / mL .The coefficient correlation for the linear curve equation Y=0.037x+0.004, is 1.00. From the average absorbance value of 0.2902, analytical, statistical and optical parameters were calculated and found to be within limits. An average recovery of the solution was made to 94.6%. The proton NMR spectrum of Alprazolam and its derivative were recorded to verify the possible mechanism which is also to supported by HPLC.