With the increasing use of poorly soluble drugs, appear problems in production different dosage forms include these substances and in its bioavailability, and therefor in its affects and efficacy, especially for oral ones, and one of the most effective factors, that determine the efficacy of the drug in the body, are the solubility extent of this drug in gastrointestinal track. There are many ways to enhance the solubility of such drugs, such as micronisation of its particles, which increases its surface, other routes are to use the drug as salt form, use co-solvents, use micelles solutions, manipulating its crystal habit, etc (4). these methods depend very much on the physical and chemical properties of the used substance, therefor we cannot assure the success of such methods, as well asthese materials show a lot of technological problems during its producing. In this study we work on different way of paracetamol crystallization, we study the produced crystals of each rotes, we determine its pharmaceutical properties, its compressibility and its different physical characteristics, and we study the tablets that produced using each type of these crystals