Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 7

Ligating, Spectral and Thermal Properties of Febuxostat Metal Complexes

Abstract

Nine complexes of febuxostat with some transition metals [Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)] were synthesized and discussed. The infrared spectra proved that febuxostat act as a bidentate ligand. The electronic spectra and magnetic measurements proved that all complexes have octahedral geometry except copper has triagonal bipyramidal geometry which confirmed by ESR. The thermal decomposition mechanisms of febuxostat and its metal complexes were studied and suggested from the DTA and TG curves. All complexes were thermally decomposed and ended by formation of the metal oxides except the complex of mercury.