Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 6

Kinetics, equilibria studies and antimicrobial activity of Iodomethyl (ligand) Cobaloximes and their role as DNA binding and Photocleavage agents

Abstract

A series of Iodomethyl complexes with various N-don or ligands were synthesized & characterized by UV/VIS, IR, MS, 1 H & 13 C -NMR spectral methods. Pseudo first order reactio n kinetics and binding studies of [ICH 2 Co(DH) 2 OH 2 ] complex with aliphatic primary amines, aromatic and heteroaromatic amines such as Methylamine, Ethylami ne, Propylamine, Aniline, Benzyl amine, Phenylalanine, Pyridine, and Amino pyridine were i nvestigated. Comparison of equilibrium constants and rate constants indicates that the ord er is K PA >K EA >K MA ; K APy >K Py ; K BA >K aniline ; the rate of substitution of H 2 O varies with the pKa of the incoming ligand establ ishing the existence of nucleophilic participation of the liga nd in the transition state. The DNA binding properties of [ICH 2 Co(DH) 2 OH 2 ] complex was investigated by absorption, emission & viscosity measurements. Photo activated cleavage of pBR-322 D NA by this complex was also studied. Further, all these cimplexes were screened for thei r antimicrobial activity.