Original Articles: 2010 Vol: 2 Issue: 4
Isolation and Comparative Evaluation of Cordia dichotoma Forst.Mucilage as a Binding Agent with Standard Binder
Cordia dichotoma Forst. found wild in the forest region, drupe usually single seeded containing mucilage. To isolate mucilage pulp is removed and the seed were macerated with water then filter. Acetone precipitation method is used to isolate mucilage from filtrate and dried in vacuum dryer at 40o C. The physicochemical characteristic of mucilage has performed such as swelling index, solubility, loss on drying. This study was carried out to compare the binding effects of isolated mucilage with starch. Granule properties such as angle of repose, moisture content, bulk and tapped densities, Hausner’s ratio, Carr’s index and tablet properties which included weight uniformity, friability, disintegration times, and dissolution rates using standard methods. Mucilages of varying concentrations of 8, 10 and 12%w/w were used to produce aceclofenac granules by wet granulation method and compressed into tablets at arbitrary pressure load unit of 6 tons. An increase in binder concentration led to decrease in friability and increase in disintegration time of the tablets. The results indicate that mucilage obtained from Cordia dichotoma Forst. fruit possesses comparable binding properties.