Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

In-vitro studies of various carbonyl derivatives on liver alkaline phosphatase


The present work describes the effect of semicarbazones, thiosemicarbazones, hydrazones and phenyl hydrazones of simple aryl aldehydes on the activity of liver alkaline phosphatase. The structural moieties under investigation have gained considerable attention in the field of parasitic and infective diseases. These compounds are reported as potent inhibitors of cruzain, falcipain and rhodesain of infecting parasites. We propose that the molecules which possess potential therapeutic activities should also be screened for their effect on the activities of physiologically important enzymes of the hosts. In the present work we have evaluated the effect of semicarbazones, thiosemicar