A series of ethyl 2-[(3-methyl-2-oxoquinoxalin-1(2 H )-yl)acetyl]-3-oxo-2,3-dihydro-1 H - pyrazole-4-carboxylate derivatives were prepared an d evaluated for their antitubercular activities. All compounds were screened for in vitro antitubercular activity against Mycobacterium tuberculosis H 37 Rv (MTB). Minimum inhibitory concentrations were determined and interpreted for Mycobacterium tuberculosis H 37 Rv according to the procedure of the approved macro dilution reference method of ant imicrobial susceptibility testing. Among all the compounds synthesized, (GKR 4b, 4c, and 4f) wer e found to be the most active compounds against MTB with MIC (25 μ g/mL).