To know whether the generic formulations of Amoxici llin Trihydrate is as effective as branded formulat ion. A branded, generic branded and generic version of Amo xicillin trihydrate dispersible tablets were procur ed and coded as A, B and C. They were compared for the disintegr ation time, dissolution time and in-vitro antimicro bial activity. The disintegration time was measured using the disi ntegration apparatus. The dissolution rate (0.1 N H Cl at 37 0 C) was measured using USP2 paddle apparatus. The antim icrobial activity was assessed on E.coli grown on M ueller Hinton agar. The disintegration times were (A) 21 s econds, (B) 51 seconds and (C) 80 seconds. The diss olution rates at 15 minutes were 98.1%, 95.7% and 83.9%. Th e zone of inhibition was found to be (A) 2.9 cms, ( B) 2.6 cms and (C) 2.2 cms. The results show that the 3 produc ts are similar and interchangeable.