Pomegranate is one of medicinal plants which were used for along time ago in treating many diseases. Lots of the studies carried out on the fruits of pomegranate peel extract showed that its content of antibiotics is capable of inhibiting the growth of bacteria and some species of parasites and fungus. In this study three extracts of sweet Pomegranate(Punica granatumL.)peels and three extracts of sour Pomegranate peels were prepared by using three solvents (Methanol – Ethanol – Distilled water). The antibacterial effect of the previous extracts was studied against Pseudomonas aeruginosa by using agar well diffusion method, also it was compared to Ciprofloxacin as a reference drug. The results showed that the Methanolic extracts of Sweat and sour pomegranate peels possess a high efficiency close to the potency of Ciprofloxacin against Pseudomonas aeruginosa.