Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Intermolecular interaction studies in some amino acids with aqueous NaOH


The ultrasonic Studies in liquids are great use in understanding the nature and strength of molecular interactions. The ultrasonic studies of biological materials in aqueous medium are ionized & can act as knowledge of the acid- base properties of proteins. The thermoacoustic analysis in biological medium would be interesting to discuss nonlinear behaviour with respect to concentrations and temperatures. Ultrasonic studies may throw more light on the molecular interactions to know the behaviour of biological macromolecules in aqueous solution. It is the key to solve the critical problems with the role and interaction of these substances in living organisms.Ultrasonic velocities, densities, viscosities, relaxation time and ultrasonic absorption of amino acids L-Histidine, L-Arginine, L-Cysteine, and LTyrosine in 1M Aqueous NaOH solutions have been measured as a function of amino acid concentration at different temperature (298.15K, 303.15K, 308.15K and 313.15K) using pulse echo overlap technique of frequency 2 MHz. Using density and ultrasonic velocity data, volume expansivity, reduced volume, Moelwyn-Hughes parameter, Bayer’s nonlinearity parameter, Gruneisen parameters, fractional free volume, repulsive exponent, internal pressure, cohesive energy density, etc. values have been computed. The formation of Zwitterions Na+/OH- water dipole aggregates in solutions causes the release of water associated with Zwitterions to bulk water. The trends in the behaviour of said thermoacoustic properties with changes in the concentration of amino acids as well as in temperature have been discussed in terms of Zwitterions-ions, Zwitterions- water dipoles, ions-ions, ions-water dipole, intermolecular and interionic interaction operative in the said systems. The nonlinear variation of thermoacoustic parameters have been also discussed in light of complex formation in the solutions.

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