In the present study the nephroprotective potential of aqueous and diethyl ether extract of Pongamia p innata flowers were assessed in lead acetate induced nephrotoxic r ats. The oral administration of water soluble fract ion of the diethyl ether extract at a dose of 150 mg/kg b.wt/ day for 90 days exhibited a significant (P < 0.05) reduction in the levels of urea, uricacid and creatinine compared to the aqueous extract treated rats. The renal marker of kidney toxicity such as urea, uricacid and creatinine and antioxidants like enzymatic and non-enzymatic were changed significantly in lead acetate treated rats. Treatme nt with water soluble fraction of diethyl ether ext ract and aqueous extract of Pongamia pinnata flowers restored the ab ove altered parameters significantly in lead acetat e inducted animals. The water soluble fraction of the diethyl ether extract showed a more efficient antinephrotox ic effect compared to the aqueous extract.